IgG-cryoglobulin consisting of both .KAPPA. and .LAMBDA. light chains and .BETA.1C/1A.
نویسندگان
چکیده
منابع مشابه
Response to therapy in IgG myeloma patients excreting lambda or kappa light chains: CALGB experience.
Sixty-eight previously untreated patients with IgG myeloma who were entered into five protocols of Cancer and Leukemia Group B (CALGB) were studied in order to determine the possible influence of excretion of kappa versus lambda urinary light chains on responses to treatment and survival. All patients in these protocols were included if the serum and urine protein abnormalities were confirmed b...
متن کاملReference values for immunoglobulin kappa and lambda light chains and the kappa/lambda ratio in children's serum.
We analyzed 708 serum samples from healthy children and adolescents by immunonephelometry to obtain reference values for the immunoglobulin kappa (kappa) and lambda (lambda) light chains and for their ratio at a time of life when immunoglobulin synthesis is maturing and continually being stimulated. The lambda chain concentration that is to be maintained throughout the child's life is reached v...
متن کاملComparing domain interactions within antibody Fabs with kappa and lambda light chains
IgG antibodies are multi-domain proteins with complex inter-domain interactions. Human IgG heavy chains (HCs) associate with light chains (LCs) of the κ or λ isotype to form mature antibodies capable of binding antigen. The HC/LC interaction involves 4 domains: VH and CH1 from the HC and VL and CL from the LC. Human Fabs with κ LCs have been well characterized for their unfolding behaviors and ...
متن کاملCerebrospinal fluid free kappa light chains versus IgG findings in neurological disorders: qualitative and quantitative measurements.
In this study free kappa light chains in cerebrospinal fluid (CSF) were determined both by an affinity mediated capillary blotting technique after isoelectric focusing (IEF) in agarose gel and by a quantitative enzyme linked immunosorbent assay (ELISA). The free kappa results were compared with the IgG findings in 4 neurological patient groups with a distinct CSF IgG pattern: (1) CSF without ol...
متن کاملTriphenotypic multiple myeloma expressing kappa or lambda light chain or both
A 70-year-old man presented with a 6-year history of oedema of both lower extremities. Ultrasonic examination showed bilateral anterior tibial artery occlusion due to thrombosis, moderate bilateral pleural effusions and ascites. He had severe pancytopenia, chronic renal dysfunction (serum creatinine 223 8 lmol/l and more than 1 g/24 h of urinary protein) and, on ultrasound examination, mildly e...
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ژورنال
عنوان ژورنال: The Tohoku Journal of Experimental Medicine
سال: 1979
ISSN: 0040-8727,1349-3329
DOI: 10.1620/tjem.129.295